Abstract: A sensitive method based on a geometry-independent neutral desorption (GIND) in combination with extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection of illicit additives such as sulfonamides and hormones in highly viscous cosmetic products. The method gave a low limit of detection (LOD) (in the range of 0.001–1 ng/g), acceptable relative standard deviation (RSD = 6.8–11.4%) and reasonable recovery (87–116%) for direct measuring of nine types of hormones and sulfonamides in the cosmetic products. The average measurement time for two types of samples was less than 1min. Trace amounts of analytes in commercial cosmetic products have been quantitatively detected, without any sample pretreatment. The experimental results showed that non-volatile illicit additives such as sulfonamides and hormones could be sensitively liberated using the GIND device for quantitative detection from the highly viscous cosmetic products, demonstrating thatGIND-EESI-MS is a promising tool for high throughput, sensitive and quantitative analysis of highly complex viscous samples. Copyright_c 2011 JohnWiley & Sons, Ltd.

Keywords: ND; EESI; viscous samples; cosmetic products; hormones; sulfonamides; quantitative detection; high throughput analysis  

2011-Yan Liu-J.MASS. SPECTROM.pdf